CXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDK.

@article{Valente2001CXCR4ID,
  title={CXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDK.},
  author={Susana T. Valente and Chantal Chanel and Julie Dumonceaux and Rene Olivier and Stefano Marullo and Pascale Briand and Uriel Hazan},
  journal={Journal of virology},
  year={2001},
  volume={75 1},
  pages={439-47}
}
Macrophages and T cells infected in vitro with CD4-dependent human immunodeficiency virus type 1 (HIV-1) isolates have reduced levels of CD4 protein, a phenomenon involved in retroviral interference. We have previously characterized the first CD4-independent HIV-1 X4 isolate m7NDK, which directly interacts with CXCR4 through its mutated gp120. We thus investigate CXCR4 expression in cells infected with this m7NDK CXCR4-dependent HIV-1 mutant. We present evidence of the down-regulation of CXCR4… CONTINUE READING