CXCR4 function requires membrane cholesterol: implications for HIV infection.

@article{Nguyen2002CXCR4FR,
  title={CXCR4 function requires membrane cholesterol: implications for HIV infection.},
  author={Dzung H. Nguyen and Dennis D. Taub},
  journal={Journal of immunology},
  year={2002},
  volume={168 8},
  pages={4121-6}
}
HIV requires cholesterol and lipid rafts on target cell membranes for infection. To elucidate a possible mechanism, we determined that cholesterol extraction by hydroxypropyl-beta-cyclodextrin (BCD) inhibits stromal cell-derived factor 1alpha (SDF-1alpha) binding to CXCR4 on T cell lines and PBMCs. Intracellular calcium responses to SDF-1alpha, as well as receptor internalization, were impaired in treated T cells. Loss in ligand binding is likely due to conformational changes in CXCR4 and not… CONTINUE READING

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