CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peritumoral T2-weighted magnetic resonance imaging signal abnormalities.

@article{Stevenson2008CXCR4EI,
  title={CXCR4 expression is elevated in glioblastoma multiforme and correlates with an increase in intensity and extent of peritumoral T2-weighted magnetic resonance imaging signal abnormalities.},
  author={Charles Stevenson and Moneeb Ehtesham and Kathryn M. McMillan and J. Gerardo Valadez and Michael L Edgeworth and R. R. Price and Ty William Abel and Khubaib Y Mapara and Reid Carleton Thompson},
  journal={Neurosurgery},
  year={2008},
  volume={63 3},
  pages={560-9; discussion 569-70}
}
OBJECTIVE With the objective of investigating the utility of CXCR4, a chemokine receptor known to mediate glioma cell invasiveness, as a molecular marker for peritumoral disease extent in high-grade gliomas, we sought to characterize the expression profile of CXCR4 in a large panel of tumor samples and determine whether CXCR4 expression levels within glioblastoma multiforme might correlate with radiological evidence of a more extensive disease process. METHODS Freshly resected tumor tissue… CONTINUE READING
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