CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis

@article{Yasuoka2008CXCR4EI,
  title={CXCR4 expression in papillary thyroid carcinoma: induction by nitric oxide and correlation with lymph node metastasis},
  author={Hironao Yasuoka and Rieko Kodama and Mitsuyoshi Hirokawa and Yuuki Takamura and Akira Miyauchi and Tokio Sanke and Yasushi Nakamura},
  journal={BMC Cancer},
  year={2008},
  volume={8},
  pages={274 - 274}
}
Metastasis to regional lymph nodes is a common step in the progression of cancer. Recent evidence suggests that tumor production of CXCR4 promotes lymph node metastasis. Nitric oxide (NO) may also increase metastatic ability in human cancers. Nitrite/nitrate levels and functional CXCR4 expression were assessed in K1 and B-CPAP papillary thyroid carcinoma (PTC) cells after induction and/or inhibition of NO synthesis. CXCR4 expression was also analyzed in primary human PTC. The relationship… CONTINUE READING

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