CXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulation

@inproceedings{Carlisle2009CXCR4EH,
  title={CXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulation},
  author={Alex J Carlisle and Christopher A Lyttle and Rosalind Y Carlisle and John M. Maris},
  booktitle={Molecular Cancer},
  year={2009}
}
CXCR4, the receptor for the chemokine stromal-derived factor 1 (SDF-1), has been shown to mediate many of the processes essential for cancer progression such as tumor cell proliferation, metastasis, and angiogenesis. To understand the role of CXCR4 in the biology of neuroblastoma, a disease that presents with wide spread metastases in over 50% of patients, we screened ten patient derived-neuroblastoma cell-lines for basal CXCR4 expression and sought to identify characteristics that correlate… CONTINUE READING