CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy

  title={CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy},
  author={Daniela Maria Menichella and Belmadani Abdelhak and Dongjun Ren and Andrew K. Shum and Caroline Frietag and Richard J. Miller},
  booktitle={Molecular pain},
BACKGROUND Painful Diabetic Neuropathy (PDN) is a debilitating syndrome present in a quarter of diabetic patients that has a substantial impact on their quality of life. Despite this significant prevalence and impact, current therapies for PDN are only partially effective. Moreover, the cellular mechanisms underlying PDN are not well understood. Neuropathic pain is caused by a variety of phenomena including sustained excitability in sensory neurons that reduces the pain threshold so that pain… CONTINUE READING
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