CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy.

@article{Bhangoo2007CXCR4CR,
  title={CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy.},
  author={Sonia K. Bhangoo and Dongjun Ren and Richard J. Miller and David M Chan and Matthew S. Ripsch and Clarissa Weiss and Christian McGinnis and Fletcher A. White},
  journal={Brain, behavior, and immunity},
  year={2007},
  volume={21 5},
  pages={581-91}
}
Nucleoside reverse transcriptase inhibitors (NRTIs) are known to produce painful neuropathies and to enhance states of pain hypersensitivity produced by HIV-1 infection. It has also been observed that in some neuropathic pain models, chemokines and their receptors are upregulated, perhaps contributing to the pain state. In order to understand if chemokines are involved in NRTI-mediated sensory neuropathies, we treated rats with the anti-retroviral drug, 2',3'-dideoxycytidine (ddC), which is… CONTINUE READING
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