CXCR4 antagonist AMD3100 redistributes leukocytes from primary immune organs to secondary immune organs, lung, and blood in mice.

@article{Liu2015CXCR4AA,
  title={CXCR4 antagonist AMD3100 redistributes leukocytes from primary immune organs to secondary immune organs, lung, and blood in mice.},
  author={Qian Liu and Zhanzhuo Li and Ji-liang Gao and Wuzhou Wan and Sundar Ganesan and David Hugh McDermott and Philip G. M. Murphy},
  journal={European journal of immunology},
  year={2015},
  volume={45 6},
  pages={
          1855-67
        }
}
AMD3100 (plerixafor), is a specific CXCR4 antagonist approved by the FDA for mobilizing hematopoietic stem cells from bone marrow to blood for transplantation in cancer. AMD3100 also mobilizes most mature leukocyte subsets to blood; however, their source and trafficking potential have not been fully delineated. Here, we show that a single injection of AMD3100 10 mg/kg into C57Bl/6 mice rapidly mobilizes (peak ∼ 2.5 h) the same leukocyte subsets to blood as in humans. Using this model, we found… CONTINUE READING
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