CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice.

@article{Huang2013CXCR4AA,
  title={CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice.},
  author={Jun Huang and Yaning Li and Yaohui Tang and Guanghui Tang and Guo-Yuan Yang and Yongting Wang},
  journal={Stroke},
  year={2013},
  volume={44 1},
  pages={
          190-7
        }
}
BACKGROUND AND PURPOSE Inflammatory response plays a critical role in propagating tissue damage after focal cerebral ischemia. CXCL12 is a key chemokine for leukocyte recruitment. However, the role of CXCL12 and its receptor CXCR4 in ischemia-induced inflammatory response is unclear. Here we use the pharmacological antagonist of CXCR4, AMD3100, to investigate the function of CXCL12/CXCR4 in regulating inflammatory response during acute ischemia. METHODS Adult male CD-1 mice (n=184) underwent… CONTINUE READING