CXCR4 and cancer.

  title={CXCR4 and cancer.},
  author={Bungo Furusato and Ahmed Fathy Abdul Latif Mohamed and Mathias Uhl{\'e}n and Johng Sik Rhim},
  journal={Pathology international},
  volume={60 7},
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes. CXCR4 has also been found to be a prognostic marker in various types of cancer, including leukemia and breast cancer, and recent evidence has highlighted the role of CXCR4 in prostate cancer. Furthermore, CXCR4 expression is upregulated in… CONTINUE READING