CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow

@inproceedings{Beck2014CXCR4AA,
  title={CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow},
  author={Thomas C. Beck and Ana Cordeiro Gomes and Jason G Cyster and Jo{\~a}o Pedro D. Pereira},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Leukocyte residence in lymphoid organs is controlled by a balance between retention and egress-promoting chemoattractants sensed by pertussis toxin (PTX)-sensitive Gαi protein-coupled receptors (GPCRs). Here, we use two-photon intravital microscopy to show that immature B cell retention within bone marrow (BM) was strictly dependent on amoeboid motility mediated by CXCR4 and CXCL12 and by α4β1 integrin-mediated adhesion to VCAM-1. However, B lineage cell egress from BM is independent of PTX… CONTINUE READING
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