CXCR4 and CXCR7 cooperate during tangential migration of facial motoneurons.

  title={CXCR4 and CXCR7 cooperate during tangential migration of facial motoneurons.},
  author={Nicolas Cubedo and Emmanuel Cerdan and Dora Sap{\`e}de and Mireille Rossel},
  journal={Molecular and cellular neurosciences},
  volume={40 4},
Migration of facial motoneurons in the zebrafish hindbrain depends on SDF1/CXCL12 signaling. Recent studies demonstrated that SDF1 can bind two chemokine receptors, CXCR4 and CXCR7. Here we explore the expression and function of the cxcr7b gene in zebrafish hindbrain development. By the time cxcr4b-expressing motoneurons migrate from rhombomere (r) r4 to r6, expression of cxcr7b is rapidly restricted to the ventral part of r5. Inactivation of either cxcr7b or cxcr4b impairs motoneuron migration… CONTINUE READING


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