CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32.

@article{Cohen1998CXCR4AC,
  title={CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32.},
  author={Oren Cohen and Stefania Paolucci and Steven M. Bende and Marybeth Daucher and Hiroyuki Moriuchi and Masako Moriuchi and Claudia Cicala and Richard T. Davey and Bruce Baird and Anthony S. Fauci},
  journal={Journal of virology},
  year={1998},
  volume={72 7},
  pages={6215-7}
}
Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Delta32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5… CONTINUE READING
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