CXCR4 acts as a costimulator during thymic β selection

@inproceedings{Trampont2010CXCR4AA,
  title={CXCR4 acts as a costimulator during thymic β selection},
  author={Paul C. Trampont and Annie-Carole Tosello-Trampont and Yuelei Shen and Amanda Duley and Timothy P Bender and Ann E. Sutherland and Dan R. Littman and Kodi S Ravichandran},
  booktitle={Nature Immunology},
  year={2010}
}
Passage through the β-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-β gene (Tcrb) and formation of a pre-TCR on the surface of CD4−CD8− thymocytes. How other receptors influence ββ-selection is less well understood. Here we define a new role for the chemokine receptor CXCR4 during T cell development. CXCR4 functionally associated with the pre-TCR and influenced β-selection by regulating the steady-state localization of immature… CONTINUE READING

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