CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling

@inproceedings{Dubrovska2012CXCR4AM,
  title={CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling},
  author={Anna Dubrovska and Anke Hartung and Laure C. Bouchez and John R. Walker and Venkateshwar A. Reddy and Charles Y. Cho and Peter G. Schultz},
  booktitle={British Journal of Cancer},
  year={2012}
}
Background:Tamoxifen is commonly used for breast cancer therapy. However, tamoxifen resistance is an important clinical problem. Continuous treatment with conventional therapy may contribute to cancer progression in recurring cancers through the accumulation of drug-resistant cancer progenitors.Methods:To investigate signalling mechanisms important for the maintenance and viability of drug-resistant cancer progenitors, we used microarray analysis, PCR array for genes involved in cancer drug… CONTINUE READING
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