CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.

@article{Burger2006CXCR4AK,
  title={CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.},
  author={Jan A Burger and Thomas J. Kipps},
  journal={Blood},
  year={2006},
  volume={107 5},
  pages={1761-7}
}
Signals from the microenvironment have a profound influence on the maintenance and/or progression of hematopoietic and epithelial cancers. Mesenchymal or marrow-derived stromal cells, which constitute a large proportion of the non-neoplastic cells within the tumor microenvironment, constitutively secrete the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). CXCL12 secretion by stromal cells attracts cancer cells, acting through its cognate receptor, CXCR4, which is expressed by both… CONTINUE READING
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