CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells.

@article{Choi2014CXCR4BN,
  title={CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells.},
  author={Young Hyun Choi and Marie D. Burdick and Brett A. Strieter and Borna Mehrad and Robert M. Strieter},
  journal={Molecular cancer research : MCR},
  year={2014},
  volume={12 1},
  pages={38-47}
}
UNLABELLED Chemokines have been implicated as key contributors of non-small cell lung cancer (NSCLC) metastasis. However, the role of CXCR7, a recently discovered receptor for CXCL12 ligand, in the pathogenesis of NSCLC is unknown. To define the relative contribution of chemokine receptors to migration and metastasis, we generated human lung A549 and H157 cell lines with stable knockdown of CXCR4, CXCR7, or both. Cancer cells exhibited chemotaxis to CXCL12 that was enhanced under hypoxic… CONTINUE READING