CXCR3-mediated skin homing of autoreactive CD8 T cells is a key determinant in murine graft-versus-host disease.

@article{Villarroel2014CXCR3mediatedSH,
  title={CXCR3-mediated skin homing of autoreactive CD8 T cells is a key determinant in murine graft-versus-host disease.},
  author={Vadim A Villarroel and Naoko Okiyama and Gaku Tsuji and Jay T Linton and Stephen I. Katz},
  journal={The Journal of investigative dermatology},
  year={2014},
  volume={134 6},
  pages={1552-1560}
}
The pathomechanisms underlying the development of cutaneous graft-versus-host disease (GVHD) are incompletely defined. We previously reported that K14-mOVA mice expressing membrane ovalbumin (mOVA), driven by the keratin 14 (K14) promoter, developed GVHD-like mucocutaneous disease and weight loss following transfer of OVA-specific, CD8(+) OT-I T cells. In this study, we demonstrate that early in the course of disease, the kinetics of epidermal expression of C-X-C motif chemokine ligand 9 (CXCL9… CONTINUE READING

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