CXCR3 ligands are associated with the continuum of diffuse alveolar damage to chronic lung allograft dysfunction.

@article{Shino2013CXCR3LA,
  title={CXCR3 ligands are associated with the continuum of diffuse alveolar damage to chronic lung allograft dysfunction.},
  author={Michael Y Shino and S. Samuel Weigt and Ning Li and Vyacheslav Palchevskiy and Ariss Derhovanessian and Rajan Saggar and David M Sayah and Aric L Gregson and Michael C. Fishbein and Abbas A Ardehali and Donald Jeffrey Ross and J. Lynch and Robert M. Elashoff and John A Belperio},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={188 9},
  pages={
          1117-25
        }
}
RATIONALE After lung transplantation, insults to the allograft generally result in one of four histopathologic patterns of injury: (1) acute rejection, (2) lymphocytic bronchiolitis, (3) organizing pneumonia, and (4) diffuse alveolar damage (DAD). We hypothesized that DAD, the most severe form of acute lung injury, would lead to the highest risk of chronic lung allograft dysfunction (CLAD) and that a type I immune response would mediate this process. OBJECTIVES Determine whether DAD is… CONTINUE READING
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