CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma.

@article{Jinquan2000CXCR3EA,
  title={CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma.},
  author={Tan Jinquan and Chen Jing and Henrik H. Jacobi and Claus M. Reimert and Anders Millner and Sha Quan and Jacob B Hansen and Steen Dissing and H. J. Malling and Per Stahl Skov and Lars K{\ae}rgaard Poulsen},
  journal={Journal of immunology},
  year={2000},
  volume={165 3},
  pages={1548-56}
}
CXC chemokine receptor 3 (CXCR3), predominately expressed on memory/activated T lymphocytes, is a receptor for both IFN-gamma-inducible protein-10 (gamma IP-10) and monokine induced by IFN-gamma (Mig). We report a novel finding that CXCR3 is also expressed on eosinophils. gamma IP-10 and Mig induce eosinophil chemotaxis via CXCR3, as documented by the fact that anti-CXCR3 mAb blocks gamma IP-10- and Mig-induced eosinophil chemotaxis. gamma IP-10- and Mig-induced eosinophil chemotaxis are up… CONTINUE READING
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