CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice.

@article{Schuh2002CXCR2IN,
  title={CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice.},
  author={Jane M. Schuh and Kate Blease and Cory M Hogaboam},
  journal={Journal of immunology},
  year={2002},
  volume={168 3},
  pages={1447-56}
}
The role of CXCR during allergic airway and asthmatic diseases is yet to be fully characterized. Therefore, the present study addressed the role of CXCR2 during Aspergillus fumigatus-induced asthma. Mice deficient in CXCR2 (CXCR2-/-) and wild-type counterparts (CXCR2+/+) were sensitized to A. fumigatus Ags and challenged with A. fumigatus conidia, and the resulting allergic airway disease was monitored for up to 37 days. At days 3 and 7 after conidia, CXCR2-/- mice exhibited significantly… CONTINUE READING