CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism.

@article{Khandaker1998CXCR1AC,
  title={CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism.},
  author={Masud H. Khandaker and Lingyun Xu and Rahbar Rahimpour and Glen B. Mitchell and Mark E. DeVries and J. Geoffrey Pickering and Sharwan K. Singhal and Ross D. Feldman and David Joseph Kelvin},
  journal={Journal of immunology},
  year={1998},
  volume={161 4},
  pages={1930-8}
}
The expression of the seven-transmembrane domain chemokine receptors CXCR1 and CXCR2 modulates neutrophil responsiveness to the chemoattractant IL-8 and a number of closely related CXC chemokines. In the present study, we investigated the mechanism by which bacterial LPS induces the down-modulation of IL-8 responsiveness and CXCR1 and CXCR2 expression on human neutrophils. Treating neutrophils with LPS reduced IL-8R expression to 55 +/- 5% of the control within 30 min and to 23 +/- 2% within 1… CONTINUE READING