CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.

@article{Curbishley2005CXCR3A,
  title={CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.},
  author={Stuart M. Curbishley and Bertus Eksteen and Ron P. Gladue and Patricia F. Lalor and David Howard Adams},
  journal={The American journal of pathology},
  year={2005},
  volume={167 3},
  pages={
          887-99
        }
}
T cells infiltrating the inflamed liver express high levels of CXCR 3 and show enhanced migration to CXCR 3 ligands in chemotactic assays. Moreover, CXCR 3 ligands are up-regulated on hepatic endothelium at sites of T-cell infiltration in chronic hepatitis, and their presence correlates with outcome of inflammatory liver disease. We used a flow-based adhesion assay with human hepatic endothelium to investigate the function of CXCR 3 on lymphocyte adhesion to and transmigration through hepatic… CONTINUE READING
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