CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.

@article{Fulkerson2005CXCL9IE,
  title={CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.},
  author={Patricia C. Fulkerson and Hongyan Zhu and David A Williams and Nives Zimmermann and Marc E Rothenberg},
  journal={Blood},
  year={2005},
  volume={106 2},
  pages={436-43}
}
Recently, inhibitory cytokine pathways for leukocyte chemoattraction and activation have been identified, but there is little insight into the operational mechanisms except for models that rely on simple receptor antagonism. We have previously identified the existence of a murine eosinophil inhibitory pathway mediated by the CXC chemokine ligand 9 (CXCL9, Mig [monokine induced by interferon-gamma]) that impressively blocks eosinophil chemoattraction and function, but the mechanism has remained… CONTINUE READING