CXCL8 secretion by dendritic cells predicts contact allergens from irritants.

@article{Toebak2006CXCL8SB,
  title={CXCL8 secretion by dendritic cells predicts contact allergens from irritants.},
  author={Mascha J Toebak and Paula R Pohlmann and Shakun C. Sampat-Sardjoepersad and Boudewina M. von Blomberg and Derk P. Bruynzeel and Rik J. Scheper and Thomas Rustemeyer and Susan Gibbs},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2006},
  volume={20 1},
  pages={
          117-24
        }
}
Monocyte-derived dendritic cell functions have been explored for identification of contact allergens in vitro. Current methods, including measurement of changes in cell surface marker expression (e.g. CD83, CD86) do not provide a sensitive method for detecting the sensitising potential of a chemical. In this study, we investigated whether chemokine production by monocyte-derived dendritic cells is increased upon maturation and whether chemokine production can provide methodology for the… CONTINUE READING
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