CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway.

@article{Sturm2005CXCL8MH,
  title={CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway.},
  author={Andreas Sturm and Daniel C Baumgart and Johanna Harder d'Heureuse and Angelika Hotz and Bertram J Wiedenmann and Axel Dignass},
  journal={Cytokine},
  year={2005},
  volume={29 1},
  pages={42-8}
}
BACKGROUND CXCL8 (previously known as Interleukin-8), a member of the alpha-chemokine family of chemotactic cytokines, stimulates intestinal neutrophil activation and chemotaxis. As intestinal epithelial cells have been recently shown to produce CXCL8, the aim of this study was to identify functional activities of CXCL8 on intestinal epithelial cells. METHODS The expression of CXCL8 receptors CXCR1 and CXCR2 was assessed by RT-PCR and FACS analysis in human Caco-2 and HT-29 cells. The effects… CONTINUE READING

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