CXCL8 Chemokines in Teleost Fish: Two Lineages with Distinct Expression Profiles during Early Phases of Inflammation

@article{vanderAa2010CXCL8CI,
  title={CXCL8 Chemokines in Teleost Fish: Two Lineages with Distinct Expression Profiles during Early Phases of Inflammation},
  author={Lieke M. van der Aa and Magdalena Chadzinska and Edwin Tijhaar and Pierre Boudinot and B M Lidy Verburg-van Kemenade},
  journal={PLoS ONE},
  year={2010},
  volume={5}
}
Background During the inflammatory process, chemokine CXCL8 plays a pivotal role in recruitment of human neutrophilic granulocytes. A diversity of sequences similar to CXCL8 was reported in fish, but their evolutionary relationships and functional homology with their human homolog remain unclear. Principal Findings We screened fish genomes to seek for sequences related to CXCL8. A first lineage was retrieved in all teleosts, while a second CXCL8 lineage was found in zebrafish and carp only. An… Expand
Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish.
  • J. Chen, Q. Xu, +7 authors J. Zou
  • Biology, Medicine
  • Developmental and comparative immunology
  • 2013
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