CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.

  title={CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.},
  author={Geraldine Nouailles and Anca Dorhoi and Markus Koch and Jens Zerrahn and January Weiner and Kellen Cristhina Fa{\'e} and Frida Arrey and Stefanie Kuhlmann and Silke Bandermann and Delia Loewe and Hans-Joachim Mollenkopf and Alexis Vogelzang and Catherine Meyer-Schwesinger and Hans-Willi Mittr{\"u}cker and Gayle McEwen and Stefan H. E. Kaufmann},
  journal={The Journal of clinical investigation},
  volume={124 3},
Successful host defense against numerous pulmonary infections depends on bacterial clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN accumulation can result in life-threatening lung injury. Local expression of CXC chemokines is critical for PMN recruitment. The impact of chemokine-dependent PMN recruitment during pulmonary Mycobacterium tuberculosis infection is not fully understood. Here, we analyzed expression of genes encoding CXC chemokines in M. tuberculosis-infected… CONTINUE READING
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