CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway.

@article{Ruth2006CXCL16mediatedCR,
  title={CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway.},
  author={Jeffrey H. Ruth and Christian S Haas and Christy C. Park and Mohammad A. Amin and Rita J. Martinez and G. Kenneth Haines and Shiva Shahrara and Phillip L. Campbell and Alisa Erika Koch},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 3},
  pages={765-78}
}
OBJECTIVE Rheumatoid arthritis (RA) is characterized by profound mononuclear cell (MNC) recruitment into synovial tissue (ST), thought to be due in part to tumor necrosis factor alpha (TNFalpha), a therapeutic target for RA. Although chemokines may also be involved, the mechanisms remain unclear. We undertook this study to examine the participation of CXCL16, a novel chemokine, in recruitment of MNCs to RA ST in vivo and to determine the signal transduction pathways mediating this process… CONTINUE READING

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