CXCL13 is elevated in Sjögren's syndrome in mice and humans and is implicated in disease pathogenesis.

@article{Kramer2013CXCL13IE,
  title={CXCL13 is elevated in Sj{\"o}gren's syndrome in mice and humans and is implicated in disease pathogenesis.},
  author={Jill M. Kramer and Ekaterina Klimatcheva and Thomas L. Rothstein},
  journal={Journal of leukocyte biology},
  year={2013},
  volume={94 5},
  pages={1079-89}
}
SS is an autoimmune disease. pSS affects exocrine glands predominantly, whereas sSS occurs with other autoimmune connective tissue disorders. Currently, care for patients with SS is palliative, as no established therapeutics target the disease directly, and its pathogenetic mechanisms remain uncertain. B-cell abnormalities have been identified in SS. CXCL13 directs B-cell chemotaxis and is elevated in several autoimmune diseases. In this study, we tested the hypothesis that CXCL13 is elevated… CONTINUE READING