CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization.

@article{Barone2008CXCL13CA,
  title={CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization.},
  author={Francesca Barone and Michele Bombardieri and Manuela Maria Rosado and Peter Roger Morgan and Stephen J Challacombe and Salvatore de Vita and Rita Carsetti and J S Spencer and Guido Valesini and Costantino Pitzalis},
  journal={Journal of immunology},
  year={2008},
  volume={180 7},
  pages={5130-40}
}
The chemokines (CKs) CXCL13, CCL21, and CXCL12 are known to play differential roles in the organization of the lymphoid tissues and the development of lymphoid malignancies. We investigated the expression of these CKs and their receptors in the salivary glands of Sjogren's syndrome patients with lymphoepithelial lesions (lymphoepithelial sialadenitis or LESA) and in MALT lymphoma to understand their involvement in salivary gland lymphomagenesis. We demonstrate that within salivary glands with… CONTINUE READING

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