CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells.

  title={CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells.},
  author={Jacob Hanna and Ori Wald and Debra Goldman-Wohl and Diana Prus and Gal Markel and Roi Gazit and Gil Katz and Ronit Haimov-Kochman and Nobutaka Fujii and Simcha Yagel and Amnon Peled and Ofer Mandelboim},
  volume={102 5},
In the maternal decidua, natural killer (NK) cells, characterized by lack of CD16, are found in direct contact with the fetal extravillous trophoblasts (EVTs). It is yet unknown which factors contribute to the specific homing of this unique NK subset to the decidua. In this study we analyze the chemokine receptor repertoire on various NK populations derived from the peripheral blood and decidua. We show that CXCR4 and CXCR3 receptors are preferentially expressed on CD16- NK subsets derived… CONTINUE READING
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