CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity.

@article{Smith2005CXCL12AO,
  title={CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity.},
  author={Jennifer M Smith and Priscilla A Johanesen and Michael K Wendt and David G. Binion and Michael B. Dwinell},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2005},
  volume={288 2},
  pages={G316-26}
}
Intestinal epithelial cell migration plays a key role in gastrointestinal mucosal barrier formation, enterocyte development, differentiation, turnover, wound healing, and adenocarcinoma metastasis. Chemokines, through engagement of their corresponding receptors, are potent mediators of directed cell migration and are critical in the establishment and regulation of innate and adaptive immune responses. The aim of this study was to define the role for the chemokine CXCL12 and its sole cognate… CONTINUE READING
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