CXCL12 Chemokine Expression Suppresses Human Pancreatic Cancer Growth and Metastasis

  title={CXCL12 Chemokine Expression Suppresses Human Pancreatic Cancer Growth and Metastasis},
  author={Ishan Roy and Noah P. Zimmerman and Alison Mackinnon and Susan Tsai and Douglas B. Evans and Michael B. Dwinell},
  booktitle={PloS one},
Pancreatic ductal adenocarcinoma is an unsolved health problem with nearly 75% of patients diagnosed with advanced disease and an overall 5-year survival rate near 5%. Despite the strong link between mortality and malignancy, the mechanisms behind pancreatic cancer dissemination and metastasis are poorly understood. Correlative pathological and cell culture analyses suggest the chemokine receptor CXCR4 plays a biological role in pancreatic cancer progression. In vivo roles for the CXCR4 ligand… CONTINUE READING
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