CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.

  title={CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.},
  author={Kenji Kabashima and Noriko Shiraishi and Kazunari Sugita and Tomoko Mori and Ayako Onoue and Miwa Kobayashi and Jun-ichi Sakabe and Ryutaro Yoshiki and Hirokazu Tamamura and Nobutaka Fujii and Kayo Inaba and Yoshiki Tokura},
  journal={The American journal of pathology},
  volume={171 4},
CCR7 is regarded as an essential chemokine receptor for cutaneous dendritic cell (DC) migration into the regional lymph nodes. However, complete migratory inhibition cannot be obtained in CCR7-deficient mice, suggesting that there exist other chemokine receptors involved in this process. Initially, we found that CXCR4 was highly expressed on migrated cutaneous DCs and that its ligand, CXCL12, was detected in the LYVE-1(+) lymphatic vessels in the skin. FITC-induced cutaneous DC migration into… CONTINUE READING