CXCL12-CXCR4 contributes to the implication of bone marrow in cancer metastasis.

  title={CXCL12-CXCR4 contributes to the implication of bone marrow in cancer metastasis.},
  author={Jingsheng Shi and Yibing Wei and Jun Xia and Siqun Wang and Jianguo Wu and Feiyan Chen and Gangyong Huang and Jie Chen},
  journal={Future oncology},
  volume={10 5},
The CXCL12-CXCR4 axis is postulated to be a key pathway in the interaction between (cancer) stem cells and their surrounding supportive cells in the (cancer) stem cell niche. As the bone marrow constitutes a unique microenvironment for cancer cells, the CXCL12-CXCR4 axis assists the bone marrow in regulating cancer progression. This interaction can be disrupted by CXCR4 antagonists, and this concept is being used clinically to harvest hematopoietic stem/progenitor cells from the bone marrow… CONTINUE READING
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