CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis

@inproceedings{Sun2014CXCL12CXCR4AP,
  title={CXCL12-CXCR4 axis promotes the natural selection of breast cancer cell metastasis},
  author={Yanan Sun and Xiaoyun Mao and Chuifeng Fan and Chong Liu and Ayao Guo and Shu Wen Guan and Quanxiu Jin and Bo Li and Fan Yao and Feng Jin},
  booktitle={Tumor Biology},
  year={2014}
}
CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of cancer cells. They have been shown to play an important role in regulating metastasis of breast cancer to specific organs. High CXCR4 expression was also correlated to poor clinical outcome. Previous study also showed that tumor cells express a high level of CXCR4 and that tumor metastasis target tissues (lung, liver, and bone) express high levels of the ligand CXCL12, allowing tumor cells to directionally… CONTINUE READING
Highly Cited
This paper has 401 citations. REVIEW CITATIONS