CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.

  title={CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.},
  author={Sandra Liekens and Dominique Schols and Sigrid Hatse},
  journal={Current pharmaceutical design},
  volume={16 35},
Chemokines are key players in the attraction and activation of leukocytes and are thus implicated in the recruitment of immune cells at sites of infection and/or inflammation. They exert their action by binding to seven-transmembrane G protein-coupled receptors. The chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 represents the single natural ligand for the chemokine receptor CXCR4. CXCL12 possesses angiogenic properties and is involved in the outgrowth and metastasis of CXCR4-expressing… CONTINUE READING


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