CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer.

@article{Izumi2016CXCL12CXCR4AB,
  title={CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer.},
  author={Daisuke Izumi and Takatsugu Ishimoto and Keisuke Miyake and Hidetaka Sugihara and Kojiro Eto and Hiroshi Sawayama and Tadahito Yasuda and Yuki Kiyozumi and Takayoshi Kaida and Junji Kurashige and Y U Imamura and Yukiharu Hiyoshi and Masaaki Iwatsuki and Shiro Iwagami and Yoshifumi Baba and Yasuo Sakamoto and Yuji Miyamoto and Naoya Yoshida and Masayuki Watanabe and Hiroshi Takamori and Norie Araki and Patrick O. B. Tan and Hideo Baba},
  journal={International journal of cancer},
  year={2016},
  volume={138 5},
  pages={1207-19}
}
Cancer-associated fibroblasts (CAFs) are reportedly involved in invasion and metastasis in several types of cancer, including gastric cancer (GC), through the stimulation of CXCL12/CXCR4 signaling. However, the mechanisms underlying these tumor-promoting effects are not well understood, which limits the potential to develop therapeutic targets against CAF-mediated CXCL12/CXCR4 signaling. CXCL12 expression was analyzed in resected GC tissues from 110 patients by immunohistochemistry (IHC). We… CONTINUE READING
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