CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo.

  title={CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo.},
  author={Frank D Antonicelli and Johanna Lorin and Sandrine Kurdykowski and Sophie C. Gangloff and Richard Le Naour and Jean Michel Sallenave and William G Hornebeck and F Grange and Philippe Bernard},
  journal={The British journal of dermatology},
  volume={164 4},
BACKGROUND Melanoma is often infiltrated by inflammatory and immune cells that might either maintain chronic inflammation, therefore promoting tumour growth, or mount an antitumour response to control tumour outcome. In this setting, Th1-oriented lymphocyte infiltration is associated with a better outcome in melanoma. Although the interferon-induced protein CXCL10 is expressed by Th1 immune cells, its receptor was also shown to be involved in melanoma progression and metastasis. OBJECTIVES To… CONTINUE READING

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