CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study

  title={CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study},
  author={Raffaele Altara and Marco Manca and M. H. M. Hessel and Yumei Gu and Laura C. Vark and K Martijn Akkerhuis and Jan A. Staessen and Harry A. J. Struijker‐Boudier and George W Booz and W Matthijs Blankesteijn},
  journal={Journal of Cardiovascular Translational Research},
Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal… 

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