CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation.

@article{Cabiolu2005CXCL12stromalCF,
  title={CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation.},
  author={Neslihan Cabioğlu and Justin M. Summy and Claudia Miller and Nila U. Parikh and Aysegul A. Sahin and Sitki Tuzlali and Kevin M Pumiglia and Gary E. Gallick and Janet E. Price},
  journal={Cancer research},
  year={2005},
  volume={65 15},
  pages={6493-7}
}
Experimental evidence suggests that CXCR4, a Gi protein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1alpha (SDF-1alpha), plays a role in breast cancer metastasis. Transactivation of HER2-neu by G protein-coupled receptor activation has been reported as a ligand-independent mechanism of activating tyrosine kinase receptors. We found that SDF-1alpha transactivated HER2-neu in the breast cancer cell lines MDA-MB-361 and SKBR3, which express both CXCR4 and HER2-neu. AMD3100… CONTINUE READING

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