CXC chemokines in angiogenesis.

@article{Strieter2005CXCCI,
  title={CXC chemokines in angiogenesis.},
  author={Robert Strieter and Marie D. Burdick and Brigitte N. Gomperts and John A Belperio and Michael P. Keane},
  journal={Cytokine \& growth factor reviews},
  year={2005},
  volume={16 6},
  pages={
          593-609
        }
}

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CXC chemokines in angiogenesis of cancer.
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These studies support the notion that the net biological balance in the magnitude of expression of angiogenic and angiostatic CXC chemokines at either the site of wound repair or during tumorigenesis may be important in the regulation of net angiogenesis.
CXC chemokines in angiogenesis
TLDR
In contrast, members that are inducible by interferons and lack the ELR motif (ELR−) are potent inhibitors of angiogenesis, a difference in angiogenic activity that may impact on the pathogenesis of a variety of disorders.
Role of Chemokines in Angiogenesis: CXCL12/SDF‐1 and CXCR4 Interaction, a Key Regulator of Endothelial Cell Responses
TLDR
The evidence supporting the direct contribution of different chemokine subfamily members, including CC, CXC, and CX3C chemokines, as positive or negative regulators of the angiogenesis process based on the expression of their cognate receptors on endothelial cells is discussed.
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A functional role of the ELR motif is suggested in determining the angiogenic or angiostatic potential of CXC chemokines, supporting the hypothesis that the net biological balance between angiogenicity and angiOSTatic CXCs may play an important role in regulating overall angiogenesis.
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It is demonstrated here that overexpression of the ELR-CXC chemokine MIG, by three different strategies including gene transfer, results in the inhibition of NSCLC tumor growth and metastasis via a decrease in tumor-derived vessel density.
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TLDR
In addition to their in vitro and in vivo actions on haemopoietic precursors, chemokines can also modulate angiogenesis and some may activate leucocytes, and more ligands and receptors will undoubtedly be discovered.
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