CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.

@article{Hoogewerf1995CXCCC,
  title={CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes.},
  author={Arlene J. Hoogewerf and Joseph W. Leone and I. M. Reardon and W. J. Howe and Darwin Asa and Robert L. Heinrikson and S R Ledbetter},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 7},
  pages={3268-77}
}
Heparan sulfate proteoglycans at cell surfaces or in extracellular matrices bind diverse molecules, including growth factors and cytokines, and it is believed that the activities of these molecules may be regulated by the metabolism of heparan sulfate. In this study, purification of a heparan sulfate-degrading enzyme from human platelets led to the discovery that the enzymatic activity residues in at least two members of the platelet basic protein (PBP) family known as connective tissue… CONTINUE READING
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