CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury.

@article{Vanderbilt2003CXCCA,
  title={CXC chemokines and their receptors are expressed in type II cells and upregulated following lung injury.},
  author={Jeff N Vanderbilt and Edward M. Mager and Lennell Allen and Teiji Sawa and Jeanine P. Wiener-Kronish and Robert Gonzalez and Leland G. Dobbs},
  journal={American journal of respiratory cell and molecular biology},
  year={2003},
  volume={29 6},
  pages={661-8}
}
The proinflammatory CXC chemokines GRO, CINC-2alpha, and macrophage inflammatory protein (MIP)-2 are a closely related family of neutrophil chemoattractants. Here, we report that freshly isolated alveolar Type II (TII) cells express these chemokine mRNAs at much higher levels than do freshly isolated Type I cells or alveolar macrophages (AM). TII cells also express CXCR2, the receptor for these chemokines. Lung injury caused by acid or Pseudomonas aeruginosa (Pa) caused an increase in TII cell… CONTINUE READING