CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis.

  title={CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis.},
  author={Kakuri M Omari and Gareth R. John and Stuart C. Sealfon and Cedric S Raine},
  journal={Brain : a journal of neurology},
  volume={128 Pt 5},
Subsequent to demyelination in multiple sclerosis, myelin repair occurs but, as lesions age, the ability to remyelinate diminishes. Molecular pathways underlying oligodendrocyte behaviour during CNS remyelination remain to be elucidated. In this study, we report for the first time constitutive expression of the CXC/alpha chemokine receptors, CXCR1, CXCR2 and CXCR3, on oligodendrocytes in normal adult human CNS tissue, the levels of which were upregulated in multiple sclerosis and other… CONTINUE READING


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