CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma.

@article{Chen2006CXCCR,
  title={CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma.},
  author={G-s Chen and H. Yu and C C E Lan and K C Chow and T Lin and L P Kok and M-P Lu and C-H Liu and Ming-tsang Wu},
  journal={The British journal of dermatology},
  year={2006},
  volume={154 5},
  pages={910-8}
}
BACKGROUND Chemokines and their receptors, well known for their ability to attract leucocytes, also play important roles for tumour progression. OBJECTIVES To investigate the possible involvement of chemokine receptors in the pathogenesis of cutaneous basal cell carcinoma (BCC). METHODS We performed an expression analysis of chemokine receptors using a well-characterized human BCC cell line. Upon the finding of CXCR4 expression by BCC, retroviral transduction of BCC cells with the CXCR4… CONTINUE READING