CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis

@inproceedings{Chung2010CXCCR,
  title={CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis},
  author={Soo-hyun Chung and Keisuke Seki and Byung-Il Choi and Keiko B Kimura and Akihiko Ito and Noriyuki Fujikado and Shinobu Saijo and Yoichiro Iwakura},
  booktitle={Arthritis research & therapy},
  year={2010}
}
INTRODUCTION Chemokines and their receptors are potential therapeutic targets in rheumatoid arthritis (RA). Among these, several studies suggested the involvement of CXC chemokine 4 (CXCR4) and its ligand CXC ligand 12 (SDF-1) in RA pathogenesis. However, the role of these molecules in T-cell function is not known completely because of embryonic lethality of Cxcr4- and Cxcl12-deficient mice. In this report, we generated T cell-specific Cxcr4-deficient mice and showed that the CXCR4 in T cells… CONTINUE READING

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