CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice.

@article{Oikawa2010CXCCL,
  title={CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice.},
  author={Yoichi Oikawa and Akira Shimada and Yoshifumi Yamada and Yoshiaki Okubo and Takeshi Katsuki and Toshikatsu Shigihara and Jun-ichi Miyazaki and Shosaku Narumi and Hiroshi Itoh},
  journal={The review of diabetic studies : RDS},
  year={2010},
  volume={7 3},
  pages={
          209-24
        }
}
OBJECTIVE Complete Freund's Adjuvant (CFA) is known to arrest autoimmune diabetes development in non-obese diabetic (NOD) mice. However, CFA alone cannot induce effective remission in diabetic NOD mice. Previously, we reported that anti-CXC chemokine ligand 10 (CXCL10) antibody can promote beta-cell proliferation in NOD mice. In the present study, we aimed to examine whether anti-CXCL10 plus CFA treatment can effectively reverse autoimmune diabetes development. METHODS Systemic supply of anti… CONTINUE READING