CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice.

@article{Fumagalli2013CX3CR1DI,
  title={CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice.},
  author={Stefano Fumagalli and Carlo Perego and Fabrizio Ortolano and Maria-Grazia De Simoni},
  journal={Glia},
  year={2013},
  volume={61 6},
  pages={827-42}
}
The studies on fractalkine and its unique receptor CX3CR1 in neurological disorders yielded contrasting results. We have explored the consequences of CX3CR1 deletion in ischemic (30' MCAo) mice on: (1) brain infarct size; (2) microglia dynamism and morphology; (3) expression of markers of microglia/macrophages (M/M) activation and polarization. We observed smaller infarcts in cx3cr1(-/-) (26.42 ± 7.41 mm(3) , mean ± sd) compared to wild type (36.29 ± 11.57) and cx3cr1(-/+) (34.49 ± 8.91) mice… CONTINUE READING